Botticelli’s Muse is about Renais­sance artist San­dro Bot­ti­cel­li his con­flicts with the Medici fam­i­ly of Flo­rence and the Jew­ish woman at the heart of his paint­ings. In 1477, San­dro Bot­ti­cel­li nev­er thought his life was going to be easy after being fired by his pres­ti­gious patron and friend Loren­zo de’ Medici. The artis­tic free­dom he is grant­ed by an annoy­ing new patron half his age only increas­es the artist’s paral­y­sis and depres­sion. Sandro’s cre­ative well runs dry until the day he sees Flo­ri­ana a Jew­ish weaver impris­oned in his sister’s con­vent. But obsta­cles threat­en to keep his unlike­ly muse out of reach. So begins a tale of one of the art world’s most beloved paint­ings, The Pri­mav­era, as San­dro, a con­firmed bach­e­lor, and Flo­ri­ana, a head­strong artist in her own right, enter into the most tur­bu­lent of relationships.