Orphaned at the age of ten and raised in a Yid­dish-speak­ing home, Rose Kush­n­er learned ear­ly about resilience. But in 1974, her life was cap­sized when she was diag­nosed with breast can­cer. She was fur­ther shocked by the sta­tus quo treat­ment of muti­lat­ing ampu­ta­tion of breasts, pec­toral mus­cles, and some­times even bones, with­out patients’ con­sent. Two years ear­li­er, Shirley Tem­ple Black had been the first celebri­ty to coura­geous­ly dis­cuss her mas­tec­to­my. Rose was deter­mined to do more by rad­i­cal­ly chang­ing the breast can­cer land­scape, tak­ing on America’s anti­quat­ed med­ical sys­tem and dis­in­ter­est­ed politi­cians. From her deathbed, she valiant­ly shep­herd­ed leg­is­la­tion for insur­ance cov­er­age of mam­mo­grams and breast recon­struc­tion. Eve­lyn Laud­er picked up the cause after being diag­nosed with breast can­cer in 1988. Incensed by the lack of a com­pre­hen­sive treat­ment cen­ter, pal­try research, and lack of aware­ness for the dis­ease killing women in epi­dem­ic pro­por­tions, she employed her impres­sive address book, over­saw fundrais­ing for New York City’s Eve­lyn Laud­er Breast Cen­ter and the Breast Can­cer Research Foun­da­tion, and used her world-wide net­work of cos­met­ic coun­ters to launch the now ubiq­ui­tous pink rib­bon. Rad­i­cal Sis­ters high­lights these three women whose courage sparked a move­ment that trans­formed society’s approach to breast cancer.